Background Methotrexate is a drug which is often unintentionally involved in medication misadventure. Because of its unusual dosage requirements (e.g. weekly rather than daily dosing) it is particularly associated inadvertent mistakes by patients and medical staff.  This may occur as a result of confusion by patients with other ‘daily’ medications or prescriptions being misinterpreted by nursing … More Methotrexate Toxicity

Clinical Toxicology 1 The Approach to the Poisoned Patient (Dr Lau Fei-lung) (1) Dose – It’s the Dose “that makes the poison“ LD50 = Lethal dose that kills 50% (2) Patient factors – individual factors that affect the likelihood of toxicity Resuscitation of the Poisoned Patient Self Protection (Universal Precautions) – consider your own safety first … More Clinical Toxicology – Pearls from ICEM 2014